Yao Ming & Shaquille O'Neal would be a much more comedic duo. I can actually already imagine the jokes that would take place between these two. I think that would be a match made in heaven, haha.
The villians would be Kobe (the leader of the gang), Kevin Garnett (loud mouth, arrogant but gets the job done), AI (small, but quick on his toes), and Tim Duncan (he would be the silent but deadly assasin).
The love interest would be Lisa Leslie - her character would be strong, independant but beautiful nonetheless.